MegaSporeBiotic
PLUS
With Antioxidants

100% SPORE-BASED PROBIOTIc

PLUS ANTIOxIDANTS

4 billion cfu

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MegaSporeBiotic™ PLUS is a 100% spore-based, broad-spectrum probiotic clinically shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria. MegaSporeBiotic™ PLUS boasts a 2-year shelf-life, does not require refrigeration, and maintains efficacy during antibiotic therapy.

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At A Glance
Ingredients
Dosing
Research
Reviews
Handout
I had been on Digestive Advantage for 5 years and saw little improvement. Within 3 days of being on MegaSpore I could not believe how much better I felt and still continue to feel since switching. The Best Probiotic out there!!!!
Angie BornoskiJUNE 19, 2018 AT 5:56 PM
Angie Bornoski
Our office LOVES this product. We can’t keep it on the shelf. We use the product ourselves and our patients are excited to try it. It has GREAT science behind it. We are always learning something new when we listen to Kiran talk about the products. We look forward to sharing this product with more of our patients.
Robert E. TaylorAPRIL 27, 2018 AT 11:27 AM
Robert E. Taylor
When my son was 2.5 months old he was having some colicky symptoms. Crying during nursing and a hard belly. As soon as I started taking Mega sporebiotics the symptoms disappeared! I have continued taking it and recommend it to patients with a variety of symptoms.
Erica DiCosmoDECEMBER 8, 2017 AT 2:14 PM
Erica DiCosmo
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At a Glance

The 1st probiotic to PROTECT its human host

MegaSporeBiotic PLUS is a probiotic blend of 4 Bacillus spores that have been clinically shown to maintain healthy gut barrier function and overall immunity. The bi-phasic life cycle of the Bacillus spores allows them to remain dormant in harsh environments until they reach more favourable environments like the human gastrointestinal tract. Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing in the gut. This unique probiotic blend aims to RECONDITION the gut instead of reseeding with probiotic strains that cannot survive digestion or colonize the gut. MegaSporeBiotic PLUS has quickly become a household favourite among health practitioners and consumers alike.

Handout

Ingredients

Bacillus

Licheniformis

  • Produces proteases needed for protein digestion
  • Produces full spectrum of B vitamins
Bacillus

Subtilis HU58™

  • Produces nattokinase and vitamin K2
  • Supports healthy GALT development
Bacillus

Clausii

  • Supports immune function
  • Maintains efficacy during antibiotic treatment
Bacillus

Coagulans

  • Produces L+ optical form of lactic acid
  • Supports immune function
Carotenoid

Antioxidants

  • Fight free radicals formed during digestion of foods
  • Reduce gut inflammation

Dosing Instructions

Start with 1/2 capsule or 1 full capsule with food and slowly increase to 2 capsules per day using the following protocol.

If 1 capsule every other day is too strong, try starting with 1/2 capsules or even 1/4 capsule in some cases. Possible symptoms may include abdominal cramping, loose stools, and changes in bowel movements. Though these symptoms may be uncomfortable, they are a sign that the product is working! Symptoms should resolve within 2-3 days.

Week 1
1 capsule every other day
Week 2
1 capsule daily
Week 3+
2 capsules daily

Research

McFarlin BK, Henning AL, Carbajal KM.

Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers. World J Gastrointest Pathophysiol. 2017 Aug 15; 8(3): 117–126.

Rhee KJ, Sethupathi P, Driks A, et al.

Role of commensal bacteria in development of gut-associated lymphoid tissue and preimmune antibody repertoire. J Immunol. 2004;172(2):1118-24.

De Punder K, Pruimboom L.

Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability. Front Immunol. 2015;15(6):223.

Gong Y, Li H, Li Y.

Effects of Bacillus subtilis on epithelial tight junctions of mice with inflammatory bowel disease. J Interferon Cytokine Res. 2016;36(2).

Samanya M, Yamauchi K.

Histological alterations of intestinal villi in chickens fed dried Bacillus subtilis var. natto. Comp Biochem Physiol A Mol Integr Physiol. 2002;133(1):95-104.

Tam NKM, Uyen NQ, Hong HA, et al.

The Intestinal Life Cycle of Bacillus subtilis and Close Relatives. Journal of Bacteriology. 2006;188(7):2692-2700.

“Survival of Probiotics in Simulated Gastric Fluid.”

Food Science Center Report. Silliker Labs. RPN 16663. August 24, 2013.

Gibson GR, Rouzaud G, Brostoff J, et al.

An evaluation of probiotic effects in the human gut: microbial aspects. Final Technical report. FSA project ref G01022.

Lefevre M, Racedo SM, Ripert G, et al.

Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study. Immun Aging. 2015;12:24.

Serra CR, Earl AM, Barbosa TM, et al.

Sporulation during Growth in a Gut Isolate of Bacillus subtilis. J Bacteriol. 2014;196(23):4184-4196.

Hong HA, Khaneja R, Tam NMK, et al.

Bacillus subtilis isolated from the human gastrointestinal tract. Res Microbiol. 2009;160(2):134-143.

Mandel DR, Eichas K, Holmes J.

Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med. 2010;10:1.

Marseglia GL, Tosca M, Cirillo I, et al.

Efficacy of Bacillus clausii spores in the prevention of recurrent respiratory infections in children: a pilot study. Ther Clin Risk Manag. 2007;3(1):13-7.

Urdaci MC, Bressollier P, Pinchuk I, et al.

Bacillus clausii probiotic strains: antimicrobial and immunomodulatory activities. J Clin Gastroenterol. 2004;38(6 Suppl):S86-90.

Nista EC, Candelli M, Cremonini F, et al.

Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial. Aliment Pharmacol Ther. 2004 Nov;20(10):1181-8.

Gabrielli M, Lauritano EC, Scarpellini E, et al.

Bacillus clausii as a Treatment of Small Intestinal Bacterial Overgrowth. Am J Gastroenterol. 2009;104(5):1327-8.

Di Caro S, Tao H, Grillo A, et al.

Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis. Eur J Gastroenterol Hepatol. 2005;17(9):951-60.

Ciprandi G, Tosca MA, Milanese M, et al.

Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: A pilot study. Pediatr Allergy Immunol. 2004;15(2):148-51.

Casula G, Cutting SM.

Bacillus Probiotics: Spore Germination in the Gastrointestinal Tract. App Environ Microb. 2002;68(5):2344-2352.